We thank this reviewer for his or her responses and recognition that DNL343 includes a promising potential as treatment for neurodegenerative diseases. Even though our scientific tests share some similarities to Wong et al., eLifeEarlier data from your authors had shown the consequences of genetically restoring protein synthesis by focusing on PERK

Different Kv3 channels have exceptional expression designs and biophysical Attributes and so are controlled in alternative ways by protein kinases. Within this evaluate, we go over the function, localization, and modulation of Kv3 channels and describe how ranges and Attributes of the channels are altered by improvements in ongoing neuronal exercis

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